T follicular helper cell subsets: a potential key player in autoimmunity

T follicular helper cell subsets: a potential key player in autoimmunity

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Follicular helper T (Tfh) cells are one of CD4+ helper T subsets which promote B cell maturation, activation and antigen-specific antibody production.Autoantibodies are hallmarks of autoimmune diseases, and crucial contributions of cent dyyni Tfh cells in development of these diseases are now evident.Deregulation of Tfh activities can contribute to a pathogenic autoantibody production and can play an important role in the promotion of autoimmune diseases.These days multiple researchers reported three subpopulations which has distinct effector functions in Tfh cells: Tfh1, Tfh2 and Tfh17 cells.In this review, we summarize the observed alterations in whole Tfh cells sophie allport bee curtains and subset distribution during autoimmune diseases.